Nimesulide + Paracetamol Uses Nimesulide+Paracetamol is used for pain relief. It relieves pain in conditions like headache, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis or painful menses. How Nimesulide + Paracetamol works Nimesulide + Paracetamol is a combination of two medicines: Nimesulide and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling). Nimesulide + Paracetamol is a combination of two medicines: Nimesulide and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling). Common side effects of Nimesulide + Paracetamol Nausea, Vomiting, Diarrhea, Increased liver enzymes